My lab hosted Ryan Daneshjou for the summer. Nice poster presentation by Ryan.
Ryan Daneshjou
40th Anniversary Reunion Rita Allen Foundation
Celebrating 40 years of exciting science supported by Rita Allen Foundation. I am eternally grateful for the Foundation's support of our research.
Just published: Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves.
Our collaborative work with the Srinivasan lab at OMRF just published in Genes & Development. This work spearheaded by Boksik Cha uncovers a major mechanism for development of the lymphatic vascular system.
New home in Bioengineering and Sciences Building
The laboratory has moved to a new home in a building that was just completed at the end of 2015 - Bioengineering and Sciences Building (BSB). We are located on the second floor. A very functional space with lots of natural light.
BSB building is located on the Rutford Avenue and Loop Road - across the street from the Residence Hall North.
a view from the SW corner
a view from the inside on the second floor.
a view from the SE corner
Tom Maniatis comes to UTD
My graduate advisor Dr. Tom Maniatis is visiting UTD to deliver the Green Distinguished Lecture Friday May 6, 2016.
Just Published: Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma
Our collaborative work on transcription elongation in melanoma with the Zon laboratory is finally published in Molecular Cell. This is a major tome on Hexim, spearheaded by Justin Tan and the Zon laboratory.
our work on variable elongation rates of RNA polymerase posted on bioRxiv pre-print
After many years of trying to publish our work on correlating variable elongation rate of RNA polymerase to exon definition and inclusion, I posted our work online. The first author was an extremely talented student, but has since left science to pursue a different career. As a result, this paper remained suspended in a third revision cycle until this week. I hope our data and analyses prove useful to others in the field.
Seminar at SMU
I visited Southern Methodist University on January 29th to meet the biology faculty and to give a seminar. It was a great visit learning about research that is happening at this campus. I also learned that SMU colors were previously referred to as Harvard Red and Yale Blue.
9 year anniversary
Nine years ago today in 2006, I opened my laboratory at Yale. I am grateful for all the hard work of students and fellows in the lab that contributed to our research and educational efforts. I am hopeful that we will continue our journey of discovery of genome regulation and our search for new knowledge and understanding of human health and disease for next nine years and beyond.
I am ever grateful to our supporters and sponsors; without their help we wouldn't be able to accomplish all that we have.
Just Published: HDACs positively regulate transcription elongation
Congratulations to Celeste Greer and coauthors on publication of this work on how HDACs function in transcription elongation of oncogenes: http://www.cell.com/cell-reports/abstract/S2211-1247(15)01167-5. The paper highlights our ongoing efforts to use genomics to elucidate transcriptional mechanisms of cancer genomes in an unbiased, comprehensive way.
