Today marks the 10 year anniversary for the lab. Ten years ago, I drove across from sunny San Diego to chilly New Haven in my trusty hatchback packed with two suitcases and boxes of books to start my lab in Sterling Hall of Medicine at 333 Cedar Street at Yale University. On that drive, I reminisced about Jack Kerouac's "On the Road" and Robert Pirsig's "Zen and the Art of Motorcycle Maintenance." I still think about those two books and the way I have pursued science, my passion. I am very grateful for everyone's contribution to our pursuit of new knowledge: our collaborators, students, fellows and supporters of the lab. I am especially grateful to the funding agencies and foundations that have made our work possible. We have come a long way, but the journey has just begun. More amazing things to be discovered and ideas to be explored. Thank you, everyone!