Simba successfully defended his tour de force work that spanned mouse genetics; murine cancer models; human tumor xenografts; cancer metabolism; glucose and insulin signaling; ROS and pro-oxidants; transcriptional enhancers and enhancer RNAs. All with the laser focus on developing targeted therapies for squamous carcinomas. Simba brought persistence and dedication, broad and comprehensive knowledge of the problem, innovative problem solving and creative approaches, and experimental discipline to how squamous carcinomas can be specifically targeted for elimination. So proud of Dr. Mazambani's accomplishments!