I am offering a new graduate level course on Nucleus in the Fall 2017 (advanced undergraduates are welcome). I am looking forward to discussing recent advances in our understanding of nuclear structure, processes and function. Hope to see you!
ten year anniversary
Today marks the 10 year anniversary for the lab. Ten years ago, I drove across from sunny San Diego to chilly New Haven in my trusty hatchback packed with two suitcases and boxes of books to start my lab in Sterling Hall of Medicine at 333 Cedar Street at Yale University. On that drive, I reminisced about Jack Kerouac's "On the Road" and Robert Pirsig's "Zen and the Art of Motorcycle Maintenance." I still think about those two books and the way I have pursued science, my passion. I am very grateful for everyone's contribution to our pursuit of new knowledge: our collaborators, students, fellows and supporters of the lab. I am especially grateful to the funding agencies and foundations that have made our work possible. We have come a long way, but the journey has just begun. More amazing things to be discovered and ideas to be explored. Thank you, everyone!
Clark Summer Research Program 2016
My lab hosted Ryan Daneshjou for the summer. Nice poster presentation by Ryan.
Ryan Daneshjou
40th Anniversary Reunion Rita Allen Foundation
Celebrating 40 years of exciting science supported by Rita Allen Foundation. I am eternally grateful for the Foundation's support of our research.
Just published: Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves.
Our collaborative work with the Srinivasan lab at OMRF just published in Genes & Development. This work spearheaded by Boksik Cha uncovers a major mechanism for development of the lymphatic vascular system.
New home in Bioengineering and Sciences Building
The laboratory has moved to a new home in a building that was just completed at the end of 2015 - Bioengineering and Sciences Building (BSB). We are located on the second floor. A very functional space with lots of natural light.
BSB building is located on the Rutford Avenue and Loop Road - across the street from the Residence Hall North.
a view from the SW corner
a view from the inside on the second floor.
a view from the SE corner
Tom Maniatis comes to UTD
My graduate advisor Dr. Tom Maniatis is visiting UTD to deliver the Green Distinguished Lecture Friday May 6, 2016.
Just Published: Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma
Our collaborative work on transcription elongation in melanoma with the Zon laboratory is finally published in Molecular Cell. This is a major tome on Hexim, spearheaded by Justin Tan and the Zon laboratory.
our work on variable elongation rates of RNA polymerase posted on bioRxiv pre-print
After many years of trying to publish our work on correlating variable elongation rate of RNA polymerase to exon definition and inclusion, I posted our work online. The first author was an extremely talented student, but has since left science to pursue a different career. As a result, this paper remained suspended in a third revision cycle until this week. I hope our data and analyses prove useful to others in the field.
Seminar at SMU
I visited Southern Methodist University on January 29th to meet the biology faculty and to give a seminar. It was a great visit learning about research that is happening at this campus. I also learned that SMU colors were previously referred to as Harvard Red and Yale Blue.
